Koninklijke Sporting Club Lokeren Oost-Vlaanderen (Dutch pronunciation: [ˈkoːnɪŋkləkə ˈspɔrtɪŋ ˌklɵp ˈloːkərə(n) ˌoːstˈflaːndərə(n)]; often simply called Sporting Lokeren or Lokeren) was a Belgian professional football club based in the city of Lokeren, in the province of East Flanders. The club was founded in 1923 but ceased to exist in 2020 after going bankrupt. A few days after the bankruptcy, the club announced that rather than dissolving entirely, it would merge with KSV Temse to form Lokeren-Temse, starting in the Belgian Second Amateur Division (fourth level).

Lokeren first reached the first division in 1974–75. Since then, it had a short spell in the Second Division between 1993–94 and 1995–96. Lokeren had its most successful period in the 1980s, achieving second place in the league in 1980–81 as well as a Belgian Cup final the same year. Its best European result was reaching the quarter-final of the 1980–81 UEFA Cup. In the year 2000, the club merged with K Sint-Niklase SKE. They were registered to the Royal Belgian Football Association with the matricule number 282. Lokeren's colours were white, black and yellow. They played their home games at the Daknamstadion.

In 2012, Sporting Lokeren won the Belgian Cup, the club's first-ever honours, after beating KV Kortrijk in the Cup Final. They won their second Cup just two years later, after beating Zulte Waregem 1–0.